|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
With this premise, this study examined in HeLa and other cell lines the effects of different APDs on the activation of ERK1/2 (Extracellular signal-regulated kinases) and AKT (Protein Kinase B) kinases, which may be affected in schizophrenia and bipolar disorder.
|
28283227 |
2017 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
While our previous data on GSK-3beta in postmortem brain and the recent report that there is impaired AKT1-GSK-3beta signaling in schizophrenia suggest that changes in pathways involving protein kinases such as AKT1 and GSK-3beta in schizophrenia are complex, our present data do not provide strong evidence in support of the involvement of GSK-3beta in schizophrenia.
|
15474909 |
2004 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
We sought to test whether a set of schizophrenia candidate genes regulated by hypoxia or involved in vascular function in the brain (AKT1, BDNF, CAPON, CHRNA7, COMT, DTNBP1, GAD1, GRM3, NOTCH4, NRG1, PRODH, RGS4, TNF-alpha) interacted with serious obstetric complications to influence risk for schizophrenia.
|
18195713 |
2008 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
We propose that through convergence on AKT/mTOR signaling, these genes are critical factors directing both placentation and neurodevelopment, influencing risk for SCZ through dysregulation of placental function, metabolism and early brain development.
|
31522868 |
2019 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
We measured AKT1 and GSK-3β proteins and phosphorylation in human peripheral blood mononuclear cells, functional MRI cingulate response during attentional control, behavioral accuracy during sustained attention, and response to 8 wk of treatment with olanzapine in a total of 190 healthy subjects and 66 patients with schizophrenia.
|
21187413 |
2011 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
CTD_human |
We measured AKT1 and GSK-3β proteins and phosphorylation in human peripheral blood mononuclear cells, functional MRI cingulate response during attentional control, behavioral accuracy during sustained attention, and response to 8 wk of treatment with olanzapine in a total of 190 healthy subjects and 66 patients with schizophrenia.
|
21187413 |
2011 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We examined eight polymorphisms spanning the AKT1 gene and their association with TD in our schizophrenia sample of 193 Caucasians, 76 of which with TD.
|
18838251 |
2008 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Variation in AKT1 has been associated with schizophrenia, bipolar disease and type II diabetes.
|
18395980 |
2008 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Thus, our study does not indicate that AKT1 or DTNBP1 play a role in the etiology of schizophrenia in the Finnish population.
|
17300918 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
This association is likely to reflect modulation of dopamine signaling by Akt1 kinase since striatal dopamine hyperstimulation is associated with psychosis and schizophrenia.
|
28416594 |
2017 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This analysis identified 624 genes with altered expression (208 up-regulated, 416 down-regulated) prior to antipsychotic treatment (p < 0.05) including schizophrenia-associated genes AKT1, DISC1 and DGCR6.
|
23442539 |
2013 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
These results implicate dopaminergic dysregulation as a mechanism underlying the increased rate of schizophrenia seen in DISC1 variant carriers, and provide insights into how DISC1, and potentially DISC1-interacting proteins such as AKT and GSK-3, could be used as novel therapeutic targets for schizophrenia.
|
28140405 |
2017 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
These findings fail to support AKT1 as a susceptibility gene for schizophrenia in the Taiwanese population.
|
16395129 |
2006 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
These deficits were related to SNPs from 16 genes, several previously associated with schizophrenia risk and/or involved in normal central nervous system development, including AKT, PI3K, SLC6A4, DRD2, CHRM2, and ADORA2A.
|
20691427 |
2010 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
These data suggest that the SNPs in DRD2 and AKT1 may influence the treatment response to risperidone in schizophrenia patients.
|
18855532 |
2008 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the association of genetic variation in AKT1 with neurocognition was investigated in patients with schizophrenia.
|
17464696 |
2007 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
The replication of association of variants in the AKT1 gene in a family sample with similar ethnical background as in the original study adds further evidence for involvement of AKT1 in development of schizophrenic disorders.
|
16026766 |
2005 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
LHGDN |
The replication of association of variants in the AKT1 gene in a family sample with similar ethnical background as in the original study adds further evidence for involvement of AKT1 in development of schizophrenic disorders.
|
16026766 |
2005 |
|
Schizophrenia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this review is to detail how putative schizophrenia risk genes (DISC-1, neuregulin/ErbB4, dysbindin, Akt1, BDNF, and the NMDA receptor) are involved in regulating neuroplasticity and how alterations in their expression may contribute to the disconnectivity observed in schizophrenia.
|
20951727 |
2011 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
The present results provide further evidence to support the AKT1 association with schizophrenia.
|
20421846 |
2010 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The intronic single-nucleotide polymorphism rs707284 in ERBB4 links to PI3K-AKT suppression in SZ.
|
28384043 |
2017 |
|
Schizophrenia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The current study examined the interactive effects of TCF4 and AKT1 variants with gender, family history of psychiatric disorders and ethnicity on the AAO of schizophrenia.
|
27305091 |
2016 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Taken together, these results implicate the Akt1 isoform in regulating hippocampal neuroplasticity and cognition and in contributing to the etiology of schizophrenia.
|
21049487 |
2012 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Taken together, our results do not support the hypothesis that AKT1 is a susceptibility gene for schizophrenia.
|
19931325 |
2010 |
|
Schizophrenia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Supportive of an earlier tentative association of AKT1 with schizophrenia, we also found that this AKT1 variant was associated with risk for schizophrenia.
|
18497887 |
2008 |